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Blog - New studies added during January 2021

Published: 08-01-2021

We run a search of PubMed every day to find newly-indexed articles relevant to health economics and outcomes research. In this blog, we summarise some of the key papers that have been added during January 2021.

 

Studies reporting utilities

  •  The EQ-5D-5L and EQ-5D-3L both demonstrated validity and responsiveness in older adults with substantial multimorbidity and polypharmacy. Bhadhuri 2020 Go to paper on PubMed
  • EQ-5D values improved significantly with biological DMARD therapy for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis in Brazil after 6 to 12 months. Alves de Oliveira Jr. 2020 Go to paper on PubMed
  • A systematic review found that utility weights declined consistently with increasing severity of chronic kidney disease, measured on the EQ-5D, SF-6D, HUI2 and HUI3. Cooper 2020 Go to paper on PubMed
  • The Minnesota Living with Heart Failure Questionnaire (MLHFQ) was mapped onto the Assessment of Quality of Life 8D (AQoL-8D) utility scores in adults with cardiomyopathy in Australia. Catchpool 2020 Go to paper on PubMed
  • SF-6D utility scores in survivors of colorectal cancer in China improved by a mean 0.042 with a diet and physical activity intervention and by 0.039 after physical activity alone after 12 months. Ho 2020 Go to paper on PubMed 

Studies validating a PRO instrument

  • The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and the Functional Assessment of Cancer Therapy General (FACT-G) were mapped to the EQ-5D-5L index in patients with cancer in Japan. Hagiwara 2020 Go to paper on PubMed
  • The Voice Handicap Index (VHI), Voice-Related Quality of Life (V-RQOL), Functional Assessment of Cancer Therapy - Head & Neck (FACT-H&N), European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Head and Neck (EORTC QLQ-H&N35) and University of Washington Quality of Life (UW-QOL) were validated in people undergoing speech rehabilitation after total laryngectomy in Brazil. Raquel 2020 Go to paper on PubMed
  • The four healthy days measures (HRQOL-4) was validated against a single measure of self-rated general health in the US general population. Dumas 2020 Go to paper on PubMed
  • The AOSpine PROST was validated against the SF-36 in patients with spinal trauma in the USA. Sadiqi 2020 Go to paper on PubMed
  • The Inventory to Measure and Assess imaGe disturbancE-Head & Neck (IMAGE-HN) was validated in people with head and neck cancer in the USA. Graboyes 2020 Go to paper on PubMed
  • The International Consultation on Incontinence Questionnaire-Satisfaction (ICIQ-S) was validated against the ICIQ-Male Lower Urinary Tract Symptoms (LUTS), International Prostate Symptom Score, and the ICIQ-LUTS Quality of Life in men after urological surgery for prostatic hypertrophy in the UK. Uren 2020 Go to paper on PubMed

Other PRO studies

  •  International Index of Erectile Function (IIEF) Questionnaire scores deteriorated in men after laparoscopic surgery for rectal cancer in Japan but recovered by 12 months with no further improvement. Sakamoto 2020 Go to paper on PubMed
  • Functional Assessment of Cancer Therapy-Bladder scores were not significantly different in patients with muscle-invasive bladder cancer who received neoadjuvant chemotherapy before radical cystectomy vs cystectomy alone. Kitamura 2020 Go to paper on PubMed
  • A core outcome set was developed for people undergoing major lower limb amputation for peripheral vascular disease in the UK. Ambler 2020 Go to paper on PubMed
  • EORTC QLQ-C30 scores were impaired within 8 weeks of a diagnosis of advanced cancer and was very low in 18.5% of patients in Germany and Switzerland; women had more anxiety and fatigue than men. Siemens 2020 Go to paper on PubMed
  • EORTC QLQ-C30 scores were lower in patients with cancer in Ethiopia than in matched patients in Germany; QoL scores were strongly correlated with fatigue, anxiety, and depression. Wondie 2020 Go to paper on PubMed

Studies reporting costs and resource use

  • Total cost of care for firearm-related injuries in 308 children and adolescents in the USA was $26million between 2008 and 2018; 52% required major surgery, 14% were readmitted due to complications after 1 year and 11% died. Phillips 2020 Go to paper on PubMed
  • 30-day readmission rate was 16.3% after surgery in the USA overall, 13.3% in those with adequate health literacy scores vs 22.5% in those with low health literacy. Baker 2020 Go to paper on PubMed
  • Societal costs due to prostate cancer in Stockholm, Sweden in 2016 were €64million, 62% of which was direct costs, 28% informal care and 10% productivity losses. Hao 2020 Go to paper on PubMed
  • Total monthly costs of healthcare were $13,000 to $34,000 higher in women with HER2+ breast cancer with metastatic disease than those with no metastases in the USA, with 3-year cumulative costs of $412,903 after diagnosis of metastatic breast cancer. Sussell 2020 Go to paper on PubMed

Economic evaluations

  • Targeted screening for pulmonary tuberculosis is cost-effective in Germany in asylum seekers from countries with an incidence of TB of 50 to 250/100,000, with an ICER of €15,000 to €17,000/additional case found. Wahedi 2020 Go to paper on PubMed
  • Pembrolizumab plus axitinib is unlikely to be cost-effective as first-line therapy in advanced renal cell carcinoma in the USA, with an ICER of $172,532/QALY compared with nivolumab plus ipilimumab. Watson 2020 Go to paper on PubMed
  • Modafinil is cost-effective in post-stroke fatigue in working-age adults in Australia, with a mean cost of AUD$3.60 for a minimally clinically important change of 10 points in the Multidimensional Fatigue Inventory (MFI) score, and saving almost AUD$467 million in productivity losses over 1 year nationally. Bajorek 2020 Go to paper on PubMed
  • Universal vaccination of college students pre-enrollment for meningitis B was not cost-effective in the USA overall, with an ICER of $748,129/QALY gained, but could be cost-saving during an outbreak. Chung 2020 Go to paper on PubMed
  • Adding MDMA to psychotherapy is cost-effective for severe chronic PTSD in the USA, with an ICER of $26,427/QALY gained compared with placebo plus psychotherapy. Marseille 2020 Go to paper on PubMed
  • Based on cost per DALY, phacoemulsification is more cost-effective than small incision cataract surgery in Indonesia. Rochmah 2020 Go to paper on PubMed
  • Adding atezolizumab to nab-paclitaxel is not cost-effective for advanced triple-negative breast cancer in Singapore, with an ICER of S$324,550/QALY gained. Phua 2020 Go to paper on PubMed
  • Eltrombopag is cost-effective for immune thrombocytopenia in the USA, with similar QALYs and LYG but lower costs than romiplostim. Tremblay 2020 Go to paper on PubMed
  • Tisagenlecleucel may not be cost-effective compared with usual care in high-risk relapsed paediatric acute lymphoblastic leukaemia in Canada, with an ICER of CaD$71,000 to $281,000/QALY gained. Furzer 2020 Go to paper on PubMed

Studies reporting mortality rates and trends

  • Mortality in people with COVID-19 in Italy was independently predicted by male sex (OR 2.63, 95%CI 1.42-4.90; p = 0.001), chronic liver disease (OR 5.88, 95%CI 2.39-14.46; p<0.001) and malignancies (OR 2.62, 95%CI 1.21-5.68; p = 0.015). Galiero 2020 Go to paper on PubMed 
  • Mortality in patients with COVID-19 treated in intensive care in the Netherlands was 26%, 96% had mechanical ventilation for an average of 15 days. Aleva 2020 Go to paper on PubMed
  • During lockdown for COVID-19 in India, patients with acute myocardial infarction were less likely to have urgent PCI within 12 hours and more likely to have thrombolysis; in-hospital mortality from acute coronary syndrome increased from 2.69% before COVID-19 to 7.27% during lockdown. Choudhary 2020 Go to paper on PubMed
  • Patients with COVID-19 who were randomised to hydroxychloroquine in the UK had similar 28-day mortality, longer admission and were more likely to need mechanical ventilation than those receiving usual care. Horby 2020 Go to paper on PubMed
  • 21% of patients admitted with COVID-19 in South Africa had HIV; mortality was 25% in those with and without HIV infection. Parker 2020 Go to paper on PubMed
  • A meta-analysis found that COVID-19 patients with elevated troponin I levels had a higher risk of admission to ICU, invasive mechanical ventilation and mortality. Malik 2020 Go to paper on PubMed
  • In-hospital mortality from COVID-19 was 13.2% in the Democratic Republic of Congo, independently predicted by age 40 years, obesity and chronic kidney disease. Nachega 2020 Go to paper on PubMed
  • Of patients with COVID-19 infection who had prior solid organ transplantation in the USA, 77% were hospitalised, 35% required ITU care and 16% died. Roberts 2020 Go to paper on PubMed
  • Anosmia was independently associated with lower adjusted mortality and need for intensive care in people with COVID-19 in Spain. Yalavera 2020 Go to paper on PubMed