An effortless and comprehensive approach to burden of illness reviews

Blog - New studies added to heoro.com in December 2019

Published: 02-12-2019

We update the heoro.com database every night by running a systematic search of PubMed for studies on health economics and outcomes research. In this blog, we summarise some of the key studies that have been added during the month of December 2019. 

Studies reporting utilities

  • EQ-5D and Minnesota Living with Heart Failure Questionnaire (MLHF) scores were similar in patients followed up after pacemaker fitting by telemedicine compared with those attending standard outpatient clinics; emergency visits and rehospitalisation rates were also similar. Lopez-Liria 2019 Go to paper on PubMed
  • SF-36 scores were significantly worse in European adults with atopic dermatitis than controls, with higher anxiety, depression, work impairment and healthcare resource use. Eckert 2019 Go to paper on PubMed
  • SF-36 domain scores ranged from 49.31 for role physical to 66.46 for physical functioning after surgery for vestibular schwannoma in Germany; SF-36 scores correlated with Penn Acoustic Neuroma Quality-of-Life scale PANQOL scores. Kristin 2019 Go to paper on PubMed

Studies validating a PRO instrument

  • The Spanish Treatment Burden Questionnaire (TBQ) was validated in patients with multiple sclerosis in Argentina. Ysrraelit 2019 Go to paper on PubMed
  • The Nontransfusion-dependent beta-thalassemia PRO tool (NTDT-PRO) was validated against the SF-36 and FACT-Anemia in patients with beta-thalassaemia in Italy, Lebanon, Greece, and Thailand. Taher 2019 Go to paper on PubMed
  • The Multidimensional presenteeism exposures and productivity survey for nurses (MPEPS-N) was validated as a measure of presenteeism in nurses in China. Lui 2019 Go to paper on PubMed
  • The Minnesota Living with Heart Failure Questionnaire (MLHFQ) was validated against the SF-36 in adults with heart failure in Indonesia. Kusuma 2019 Go to paper on PubMed
  • The Patient-Reported Outcomes in Obesity (PROS) was validated against the Impact of Weight Quality of Life questionnaire (IWQOL-Lite) in people undergoing bariatric surgery for obesity. Aasprang 2019 Go to paper on PubMed
  • The EORTC Questionnaire for Head and Neck Cancer (EORTC QLQ-H&N35), the Functional Assessment of Cancer Therapy General and Head and Neck (FACT-H&N), the M.D. Anderson Symptom Inventory Head and Neck questionnaire (MDASI-HN),and the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) assess different symptoms in patients undergoing radiotherapy for head and neck cancer and none completely cover patient experiences. Hollander-Mieritz 2019 Go to paper on PubMed
  • Patient-Reported Outcomes Measurement Information System (PROMIS) pediatric measures were validated as measures of changes over time in children with cancer in the USA. Hinds 2019 Go to paper on PubMed

Other PRO studies

  • PHQ-9 scores were improved by a 17-week psychosocial intervention compared with usual care in older adults with depression in Brazil. Scazufca 2019 Go to paper on PubMed
  • Psychological distress, measured on the Kessler 10-item questionnaire, affected 52.5% of adults in rural Bangladesh, 9% severe; distress was independently predicted by being older, widowed, and with no education; socioeconomic status showed a U-shaped curve. Islam 2019 Go to paper on PubMed
  • WHODAS 2.0 scores showed mild to moderate disability for mobility, life activities and participation in society domains in patients with pulmonary hypertension in Portugal; scores for cognition, self care and interpersonal relationships were lower. Reis 2019 Go to paper on PubMed
  • Community-based rehabilitation significantly increased quality of life in adults with schizophrenia in Indonesia compared with controls. Puspitosari 2019 Go to paper on PubMed
  • Schizophrenia Quality of Life Questionnaire (SQoL18) scores were higher in outpatients with stable schizophrenia in Peru and lower in Bolivia compared with those in Chile. Caqueo-Urizar 2019 Go to paper on PubMed

Studies reporting costs and resource use

  • A systematic review found that hospitalisation rates in people with dementia were between 0.37 and 1.26/person-year, a relative risk for hospitalisation of 1.42 (95%CI 1.21 to 1.66) compared with people without dementia matched for age, sex and physical comorbidity. Shepherd 2019 Go to paper on PubMed
  • Mean indirect out-of-pocket costs for caregivers of elderly patients in intensive care in Canada was $791 in the first month, $162/day. Boyes 2019 Go to paper on PubMed
  • The lifetime risk of hospitalisation for diverticular disease from age 30 years is 3.1% in men, 5% in women in Sweden, risks of intestinal resection or stoma formation are 0.5% in men and 0.8% in women. Skoldberg 2019 Go to paper on PubMed

Economic evaluations

  • In 61 endemic countries/locations, a melioidosis vaccine could avert 68,000 lost QALYs, 8300 cases and 4400 deaths per vaccinated age cohort, at an incremental cost of USD59.6 million.  Luangasanatip 2019 Go to paper on PubMed
  • Assessing baseline left ventricular function with equilibrium radionucline angiography (ERNA) is cost-effective in women about to start anthracycline and/or trastuzumab therapy for breast cancer in the USA, with an ICER of $45,473/QALY gained. Abu-Khalaf 2019 Go to paper on PubMed
  • Narrow-band imaging-guided biopsy for surveillance of Barrett's oesophagus is cost-saving over 7 years in the UK compared with random biopsies, with similar accuracy, fewer biopsies and reduced adverse events. Furneri 2019 Go to paper on PubMed
  • Laparoscopic distal pancreatectomy has similar costs and quality of life and is likely to be as cost-effective as open pancreatectomy in the Netherlands. van Hilst 2019 Go to paper on PubMed
  • Survival after resection for hepatocellular carcinoma in the USA was 652 days at a cost of $2904/day, patients receiving liver transplant survived 1579 days at a cost of $2889/day; cost-effectiveness was directly related to length of survival. Skill 2019 Go to paper on PubMed
  • Edoxaban is cost-effective compared with acenocoumarol to prevent stroke and systemic embolism in non-valvular atrial fibrillation in Spain, with an ICER of €11,518/QALY. Lekuona 2019 Go to paper on PubMed
  • Sleeve gastrectomy was the most cost-effective type of bariatric surgery in adults with nonalcoholic steatohepatitis with cirrhosis, with an ICER of $6563/QALY in severe obesity, to $66119/QALY in overweight compared with usual care. Klebanoff 2019 Go to paper on PubMed
  • Axicabtagene Ciloleucel is not cost-effective compared with chemotherapy in B-cell lymphoma in the US at 2 years with an ICER of $896,600 for public payers, but may be more cost-effective if it increases long-term survival. Whittongton 2019 Go to paper on PubMed
  • Memory assessment services may be cost-effective in the UK if patients' quality of life would have deteriorated without referral, with an ICER of £25,056/QALY; £89,546/QALY without this assumption. Gomes 2019 Go to paper on PubMed

Studies reporting mortality rates and trends

  • A systematic review found the mortality rate from cellulitis was 1.1% (95%CI 0.7 to 1.8) worldwide, and 0.5% (95% CI 0.3 to 0.9) in the USA. Gunderson 2018 Go to paper on PubMed
  • 21.7% of patients with troponin measurements in UK hospitals died after a median 1198 days; those with a raised value had HR for death of 3.2 over 3 years; HR =10.6 in adults 18-29 yr, HR =1.5 in those aged >90 yr. Kaura 2019 Go to paper on PubMed
  • Five-year age-standardised relative survival in women with cervical cancer in Sweden was 70% in 2011-2015, 95% relative survival after surgery for stage 1BI disease to 7% for stage IVB disease. Bjurberg 2019 Go to paper on PubMed
  • In Burkino Faso, 21% of infants were low birthweight; 1-year mortality was 7.8% overall, 44% of deaths were in low birthweight infants. Mwangome 2019 Go to paper on PubMed
  • 6-month survival after surgery or radiotherapy was 77% in patients with one spinal metastasis compared with 65% in those with multiple spinal metastases; EQ-5D and SF-36 scores were similar. Barzilai 2019 Go to paper on PubMed